Cancer Deaths Rising in the U.S.: A Closer Look at Subtle Symptoms You Shouldn’t Ignore

A newly released report has revealed a troubling trend in cancer mortality across the United States. Despite the overall cancer death rate continuing to decline, deaths from six specific types of cancer are on the rise in both men and women. This alarming shift highlights the urgent need for increased awareness around symptoms that may seem minor but could be early indicators of serious health conditions.

Over Two Million Cancer Cases Expected in 2025

According to the American Cancer Society, the U.S. is projected to see over 2 million new cancer diagnoses in 2025 alone. Tragically, more than 618,000 people are expected to die from the disease that year. While significant progress has been made in treatment and early detection, the rise in certain cancer death rates underscores a critical gap in timely diagnosis—often due to symptoms that are easy to overlook or dismiss.

Between 2018 and 2022, death rates rose in both men and women from six types of cancer: skin cancer (non-melanoma), oral cavity and pharynx (throat) cancer, bone and joint cancer, pancreatic cancer, uterine (womb) cancer, and liver cancer.

Here’s a breakdown of each, including symptoms you should never ignore:

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1. Skin Cancers

Skin cancer is one of the most common forms of cancer in the U.S., and while many people associate it with visible moles or sunburn, some warning signs are more subtle.

Key symptoms include:

• A sore or skin area that doesn’t heal within 4 weeks

• A spot that looks unusual or feels itchy

• A lesion that bleeds, scabs, or crusts over repeatedly

• A change in size, shape, or color of an existing mole

Important note: The report emphasizes an increase in non-melanoma skin cancer deaths in men, suggesting a need for better awareness and sun protection habits, especially among older adults.

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2. Oral Cavity and Pharyngeal Cancers

These cancers affect the mouth, throat, and back of the tongue. Deaths from these cancers have increased in both genders.

Symptoms you might overlook:

• Persistent ulcers in the mouth that don't heal

• Red or white patches inside the mouth or on the tongue

• Difficulty swallowing or a sore throat that doesn’t go away

• Lumps in the neck or unexplained weight loss

• Persistent bad breath

Tip: If symptoms last more than three weeks, it’s time to consult your doctor.

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3. Bone and Joint Cancers (Sarcomas)

Bone cancers are relatively rare but can be particularly aggressive. They’re more common in young people but can affect adults as well.

Warning signs include:

• Pain in bones, especially at night or when resting

• Swelling or tenderness near a joint

• A noticeable lump or mass on a bone

• Reduced mobility or difficulty moving a limb

Early detection significantly improves treatment outcomes, so don’t brush off persistent or unexplained bone pain.

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4. Pancreatic Cancer

Pancreatic cancer is often dubbed a “silent killer” due to how hard it is to catch in early stages. Yet, early diagnosis is key for survival.

Common symptoms:

• Unexplained weight loss

• Jaundice (yellowing of the skin and eyes)

• Fatigue and general weakness

• Stomach pain radiating to the back

• Dark urine and greasy or pale stools

New data indicates this cancer is on the rise, especially in those over age 55. Maintaining a healthy lifestyle and paying attention to gastrointestinal changes can help with early detection.

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5. Uterine (Womb) Cancer

This cancer is most common in postmenopausal women, and recent reports show rising death rates.

Red flags include:

• Vaginal bleeding after menopause

• Abnormally heavy or irregular periods

• Pain during intercourse

• Frequent urination or pelvic pressure

If you’ve been through menopause and experience any form of bleeding, it’s essential to get checked immediately.

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6. Liver Cancer

Liver cancer is now one of the fastest-rising causes of cancer-related death in the U.S. Risk factors include obesity, diabetes, and hepatitis infections.

Symptoms that shouldn’t be ignored:

• A lump or pain on the right side of the abdomen

• Loss of appetite

• Unexplained fatigue

• Swollen abdomen or fluid retention

Liver cancer often presents late, so proactive health screenings are crucial for those at risk.

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Why This Matters More Than Ever

With more than 1 in 2 men and 1 in 3 women expected to develop cancer in their lifetimes, it’s more important than ever to be aware of the subtle signs. In many cases, early detection could mean the difference between life and death.

If you experience any of the symptoms mentioned—even if they seem minor—it’s worth talking to a healthcare professional.

For confidential cancer support or to speak with someone, contact the American Cancer Society at 1-800-227-2345 or use their 24/7 live chat.

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Stay Informed, Stay Proactive

While cancer trends can be frightening, staying informed about your body and any changes is a powerful first step in prevention. By recognizing the symptoms early and getting regular checkups, you give yourself the best possible chance at catching cancer when it’s still treatable.