TOPLINE:
A large-scale meta-analysis of 25 studies estimated that hidradenitis suppurativa (HS) affects nearly 1% of the global population. The findings highlight notable regional differences, with prevalence ranging from extremely low in some Asian countries to alarmingly high in parts of the Middle East and Europe. The analysis also confirmed that women are disproportionately affected.

METHODOLOGY:
Researchers applied the standardized Global Hidradenitis Suppurativa Atlas methodology to conduct a proportional meta-analysis. The pooled sample included 22,743 participants across 25 studies, representing 23 countries spanning six continents (notably, the United States was not among them).

Screening was conducted through validated questionnaires followed by clinical confirmation of HS diagnoses. Within the total population, 247 patients were identified with HS (55.6% women; median age, 34.5 years). The primary outcome was to establish the prevalence of HS across diverse populations, while also analyzing demographic and risk factors associated with the condition.

TAKEAWAY:

• The overall global prevalence of HS was 0.99% (95% CI, 0.67%-1.46%).

• Women were significantly more likely to have HS than men (regression coefficient, 1.02; 95% CI, 1.01-1.03). No other demographic or lifestyle factors showed a significant association.

• Lowest prevalence rates were recorded in Bangladesh (0.13%), Greece (0.18%), and Sri Lanka (0.20%).

• Highest prevalence rates were found in Saudi Arabia (4.07%), France (3.43%), Chile (2.40%), and Oman (2.07%). These striking differences underscore that HS is not uniformly distributed and may be influenced by genetics, environment, or healthcare access.

IN PRACTICE:
The authors concluded that HS is more common worldwide than previously assumed, with nearly 1 in 100 people affected. Importantly, they emphasized the “substantial regional variations” in prevalence. Such differences could reflect genetic susceptibility, diagnostic awareness, environmental influences, or cultural factors.

They also noted that further multinational research is required to better understand the reasons behind these disparities and to ensure early recognition, particularly in countries where prevalence may be underestimated. Improved screening and greater awareness could play a key role in reducing the significant physical and psychological burden associated with HS.